#Silver blue skin skin#

The most common drugs are chemotherapeutic agents, anti-acne antibiotics (tetracycline and minocycline), oral contraceptives, hydroxychloroquine, clofazimine, and amiodarone.

#Silver blue skin skin#

On the other hand, acquired hyperpigmentation of the skin or mucosae is also a frequent adverse effect of numerous treatments. Differential diagnosis includes various dermatoses of unknown etiology, such as erythema dyschromicum perstans or ashy dermatosis, lichen planus pigmentosus and melasma or argyria, which is caused by an inappropriate or accidental exposure to silver compounds. Various exogenous factors can be involved, including inflammation and injury (postinflammatory hyperpigmentation). The clinical features are characterized by blue-black or blue-gray diffuse or pitted pigmentation primarily of the face, extremities and other photo-exposed areas. The patient today, showing mild improvement after discontinuation.Дisorders of pigmentation are usually due to the deposition of melanin and an increase in active melanocytes. The patient refused any surgical procedure, such as laser treatment or skin bleaching agents. At 2 years of follow-up, the face discoloration was still present, although less prominent (Fig. Minocycline intake was immediately stopped and a diagnosis of minocycline-induced pigmentation was made. In fact, he had observed an improvement of a folliculitis of his trunk after minocycline prescription from his physician he had therefore continued to take the drug autonomously. A more detailed medical history revealed that the patient had been taking minocycline 100 mg every other day for nearly 10 years. A skin biopsy from the pigmented skin showing prominent solar elastosis, epidermal thinning, and focal hyperpigmentation of the basal layer was not helpful for a diagnosis.

Routine blood tests and other recent investigations excluded the most common causes of hyperpigmentation, including Addison disease, hyperthyroidism or malignancy. 1), while the trunk, limbs, and the mucosae were spared. Other medications included aspirin, allopurinol, simvastatin, and bisoprolol.ДЄt the time of our consultation, we observed a prominent blue-gray discoloration characterized by symmetric patches localized on the temporal, preauricular and periorbital skin (Fig. He had been followed up for 14 years following a cardiac transplantation and was under immunosuppressive treatment with numerous drugs, including cyclosporine, azathioprine, and everolimus. ДЄ 61-year-old Italian man was referred from the cardiology unit for a blue-gray discoloration of his face of 3 years' duration.

Drug-induced hyperpigmentation has commonly been described as the consequence of an increased deposition of melanin in the epidermis and/or in the dermis of the photo-exposed skin.